Dr Oliver Sutcliffe
Dr Oliver Sutcliffe CChem CSci EurChem FHEA FRSC
Reader, Director of MANDRAKE
Research-active pharmaceutical chemist working on the synthesis, analysis and harm reduction of illicit drugs and New Psychoactive Substances (NPS).
My profile
Biography
Dr Oliver Sutcliffe graduated from the University of Liverpool with a BSc (Hons) in Chemical Sciences (1996) and subsequently obtained a PhD in Synthetic Organic Chemistry (1999) under Drs Richard Storr and Thomas Gilchrist from the same institution. In 1999, he joined Professor Martin Bryce’s group at the University of Durham, before moving to industry (in 2001) and working as a medicinal chemist on the design, development and optimisation of drug molecules for a broad-range of biological targets, including cancer.
He moved to the University of Strathclyde in 2006, obtained an MSc in Pharmaceutical Analysis and after a period at the European Directorate for the Quality of Medicines and Healthcare (EDQM) in Strasbourg was appointed as a Lecturer in the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS). During this period his research focused on the synthesis, characterisation and development of methods for the detection of illicit drugs and new psychoactive substances (NPS).
In 2012, Dr Sutcliffe joined Manchester Metropolitan University as a Senior Lecturer, where his NPS research has continued to expand and led to the development of field-deployable screening technologies to aid in the prevention of trafficking/supply of psychoactive drugs. In recognition of his international contribution to the field of psychoactive substance research, Oliver was appointed a Fellow of the Royal Society of Chemistry (FRSC) (August 2016) and subsequently promoted to Reader in August 2023.
In addition to his research, Dr Sutcliffe is the Director of the MANchester DRug Analysis and Knowledge Exchange (MANDRAKE) partnership - a licenced scientific resource, based at Manchester Metropolitan University, working in partnership with key stakeholders to facilitate rapid, robust and cost-effective chemical analysis for both harm-reduction and intelligence sharing.
MANDRAKE is England’s FIRST publicly-funded permanent city-centre based testing and harm reduction facility, operating since 2016, supporting openscience and agencies working towards safeguarding the health and wellbeing of the public.
Interests and expertise
Research Interests
- Synthesis and characterisation of illicit drugs and New Psychoactive Substances (NPS)
- Development and application of “field-deployable” chromatographic and spectroscopic techniques for the analysis of psychoactive drugs
- Application of NMR to routine drug testing (see video)
- Biological evaluation of the acute and chronic health effects of psychoactive drugs
- Promoting harm reduction and understanding drug trends through rapid chemical analysis
Prospective students looking for either MSc or PhD positions are strongly encouraged to contact Dr Oliver Sutcliffe prior to applying.
Impact
Dr Sutcliffe has pioneered Manchester Met’s research on illicit drug/NPS detection and harm reduction placing our institution at the forefront of coordinated, interdisciplinary research to combat these global challenges. Our work underpins the city-region police and public authority infrastructure, strategy, monitoring, and operational decisions – leading to my research (and specifically MANDRAKE) being embedded into policy e.g., the GM Drug & Alcohol Strategy (2019–21).
His research area has been externally judged (REF2021) to have both significance and reach and he was the Lead Researcher on an impact case study (UoA3) specifically developed around his individual research and its influence on public health, safety, and wellbeing.
Also, due to the interdisciplinary nature of our work, MANDRAKE has contributed to a second impact case study (UoA20) associated informing drug policy and improving professional practice within front-line healthcare providers, as outlined below:
Getting ahead of new drug trends
Go to case study
Reducing harm posed by new psychoactive substances
Go to case studyProjects
The interdisciplinary nature of our work has enabled the research team to consistently attract income from prestigious funders from both UKRI, charitable and third-sector sources.
Dr Sutcliffe’s current research, within “Allied Health Professions, Dentistry, Nursing and Pharmacy” (UoA3) is funded by an £1.3M EPSRC grant (led by Professor Chris Pudney, University of Bath) focusing on the development of a portable device to detect synthetic cannabinoids (or Spice).
MANDRAKE provides the interdisciplinary consortium with access to synthetic cannabinoid standards, seized samples and coordinates field-deployment/testing of the technology in Greater Manchester.
In addition to this large grant, due to the impact and relevance of his work, Oliver has also won funding from other sector-relevant sources including contracts with Greater Manchester Combined Authority (GMTRENDS); HM Prison & Probation Service and Manchester City Council to promote wellbeing and reduce drug-related harms through rapid detection and quantification of substances of concern.
Our multi-method GMTRENDS research approach (with Professor Rob Ralphs) has never been adopted before in the UK. The findings will inform the work of the established Greater Manchester Local Drugs Information System (LDIS), identify at risk groups in our communities, and provide recommendations on service development, harm reduction, and wider training and awareness raising.
Download the reports (free) here:
2022 Monitoring Cycle: Executive Summary Full Report
2022 Adult Trends Focus (Chemsex): Full Report
2022 Young Persons Trends Focus (Nitrous Oxide): Full Report
2021 Monitoring Cycle: Executive Summary Full Report
Teaching
Dr Sutcliffe has >15 years of experience of research-informed teaching in universities. He has been involved teaching/assessment, management duties and have exhibited a strong commitment to research-led undergraduate and postgraduate teaching, examining and leading academic programmes.
He has embedded his research throughout his teaching, from Levels 5–7 and has published projects from three undergraduate placements (Level 5), five undergraduate projects (Level 6) and six MChem projects (Level 7). Students can see the significance of how MANDRAKE promotes drug awareness and actively reduces harm amongst their peers and as a result many opt to do projects in this area.
Dr Sutcliffe is a Fellow of the Higher Education Academy (FHEA) via the peer-reviewed, evidence-based account of practice route. Since joining Manchester Met, he been Year Tutor (2012–20) for the MChem Chemistry and MChem Medicinal & Pharmaceutical Chemistry programmes and made a significant contribution in shaping the chemistry curriculum through RSC accreditation reviews and led the design of the pharmaceutical chemistry, research-led teaching strands that are embedded throughout our degree programmes.
Dr Sutcliffe champions an inclusive, transformative student experience that has a positive impact on their personal and professional development through extracurricular activities. He employs MANDRAKE research assistants from diverse gender, cultural and ethnic backgrounds – representative of Manchester Met’s student population – to provide back-of-house testing and promote harm reduction at local events.
These opportunities engender students with a sense of pride, engages them in community-based projects and actively applies their academic skills to “real world” challenges. The team has published two papers (Paper 1 and Paper 2) from these activities and ~60% of the co-authors are Manchester Met students who have subsequently secured research posts within six months of graduation.
Courses
Supervision
Dr Sutcliffe has supervised ten PhD students and ten MRes/MPhil students to completion as Principal Supervisor. He is currently supervising another three PhD students (two as Principal Supervisor and one as 1st Supervisor).
Ms. Emily Dawber (2023 - current)
“Synthesis, detection, and hepatotoxic evaluation of novel synthetic cathinones recently identified in night-time economy settings” (Supervised with Dr Ryan Mewis and Dr James Pritchett).
Mr. David Dixon (2020 - current)
“Development of field-deployable detection methods for the rapid, sensitive and cost-effective analysis of psychoactive substances” (Supervised with Dr Ryan Mewis).
Ms. Molly Millea (2022 - current)
“Development of rapid and robust field-deployable methods, for the detection and quantification of synthetic cannabinoids” (Supervised with Dr Ryan Mewis)
Mr. Alex Wilcock (2021 - current)
“Application of the Signal Amplification By Reversible Exchange (SABRE) and SABRE-relay hyperpolarisation techniques in nuclear magnetic resonance (NMR) spectroscopy for the detection and characterisation of bioactive molecules” (Supervised with Dr Ryan Mewis).
Dr Sutcliffe’s PGR student projects have been matched-funded by industry (Oxford Instruments Limited), as well as wholly funded by the Canadian, Libyan and Saudi Governments. All his PGR students publish during their studies and, after completion, have gone on to prestigious roles, including Vice Dean (Pharmacy) at Taif University and three Associate Professorships at Omar Almukhtar, Kuwait and An-Najah National Universities.
How do I apply?? Prospective students looking for either MSc or PhD positions are strongly encouraged to contact Dr Oliver Sutcliffe prior to applying.
Research outputs
Dr Sutcliffe has published >80 research articles, which have received recognition nationally and internationally and he holds inventorships on 20 patents and demonstrates his ability to lead multidisciplinanary research from inception to dissemination..
The statistics from SCOPUS show that his articles are in top journals (~31% are in the top 10% of journals) and are well cited (>15% of publications are in the top 10% most cited worldwide and he has a field-weighted citation index of 1.28). >70% of his publications have external collaborators, with ~30% being international collaborators.
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Books (authored/edited/special issues)
Spencer, J., Sutcliffe, O.B. (2014) Microwaves in Drug Discovery and Development: Recent Advances. Future Medicine Ltd.
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Chapters in books
Sutcliffe, O.B., Mewis, R.E. (2020) 'Nuclear Magnetic Resonance Spectroscopy.' Clarke’s Analysis of Drugs and Poisons. Pharmaceutical Press,
Sutcliffe, O.B. (2014) 'Classical and microwave-assisted synthesis of cucurbit[n]urils, hemicucurbit[n]urils and bambus[n]urils.' In Spencer, J., Bagley, M. (ed.) Microwaves in Drug Discovery and Development Recent Advances. Future Medicine Ltd,
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Media
Sutcliffe, O.B. (2024) On Resonance: Using benchtop NMR for drug harm reduction.
Sutcliffe, O.B. (2024) Drugs Map of Britain - Series 2, Episode 2 - THC Vapes.
Sutcliffe, O.B. (2024) Drugs Map of Britain - Series 2, Episode 3 - Monkey Dust.
Ralphs, R., Knight, M., Sutcliffe, O.B. (2023) MetCast Podcast: Substance Use Trends in Greater Manchester.
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Reports
Sutcliffe, O.B., Erridge, S., Martinez, J. (2024) The Hidden Dangers of Illicit Cannabis. Curaleaf International.
Ralphs, R., Linnell, M., Sutcliffe, O.B. (2024) Trend Focus: Ketamine. Manchester Metropolitan University.
Ralphs, R., Linnell, M., Sutcliffe, O.B. (2024) Trend Focus: THC Vapes. Manchester Metropolitan University.
Ralphs, R., Linnell, M., Sutcliffe, O.B. (2024) Greater Manchester: Testing and Research on Emergent and New Drugs (GM TRENDS): 2023 monitoring cycle full report. Manchester: Manchester Metropolitan University.
Sutcliffe, O., Crean, C., Raithelhuber, M., Tettey, J. (2024) The challenge of New Psychoactive Substances - a technical update. Vienna: United Nations.
Ralphs, R., Linnell, M., Sutcliffe, O.B. (2023) Greater Manchester: Testing and Research on Emergent and New Drugs (GM TRENDS): 2022 monitoring cycle full report. Manchester Metropolitan University.
Ralphs, R., Linnell, M., Sutcliffe, O.B. (2023) Adult Trend Focus: substances associated with chemsex. Manchester Metropolitan University.
Ralphs, R., Linnell, M., Sutcliffe, O.B. (2021) Greater Manchester: Testing and Research on Emergent and New Drugs (GM TRENDS): 2021 monitoring cycle full report. Manchester Metropolitan University.
Caprio, V., Sutcliffe, O.B., Mewis, R. (2018) Analysis of the reduction product of 3-nitrobenzaldehyde using Pulsar. Oxford Instruments.
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Internet publications
Pym, H., Watkinson, L., Sutcliffe, O.B. (2023) Warning a child could die due to illegal drugs in vapes. https://www.bbc.co.uk/news/health-67349297.
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Journal articles
Brandon, A.M., Baginski, S.R., Peet, C., Dugard, P., Green, H., Sutcliffe, O.B., Daéid, N.N., Nisbet, L.A., Read, K.D., McKenzie, C. (2024) 'Log D7.4 and plasma protein binding of synthetic cannabinoid receptor agonists and a comparison of experimental and predicted lipophilicity.' Drug Testing and Analysis, pp. 1-14.
Craft, S., Sunderland, P., Millea, M.F., Pudney, C.R., Sutcliffe, O.B., Freeman, T.P. (2024) 'Detection and quantification of synthetic cannabinoids in seven illicitly sourced disposable vapes submitted by an individual presenting to a UK drug and alcohol service.' Addiction,
Cozier, G.E., Andrews, R.C., Frinculescu, A., Kumar, R., May, B., Tooth, T., Collins, P., Costello, A., Haines, T.S.F., Freeman, T.P., Blagbrough, I.S., Scott, J., Shine, T., Sutcliffe, O.B., Husbands, S.M., Leach, J., Bowman, R.W., Pudney, C.R. (2023) 'Instant detection of synthetic cannabinoids on physical matrices, implemented on a low-cost, ultraportable device.' Analytical Chemistry, 95(37) pp. 13829-13837.
Dixon, D.I., Millea, M.F., Wilcock, A.T.M., Costello, A., Ellison, J.R., Lord, S., O'Brian, K.A., Mewis, R.E., Sutcliffe, O.B. (2023) 'Synthesis, characterisation and quantification of the new psychoactive substance 1-(1,3-benzodioxol-5-yl)-2-(propylamino)butan-1-one (bk-PBDB, putylone).' Forensic Chemistry, 35pp. 100523-100523.
Hindson, S.A., Andrews, R.C., Danson, M.J., van der Kamp, M.W., Manley, A.E., Sutcliffe, O.B., Haines, T.S.F., Freeman, T.P., Scott, J., Husbands, S.M., Blagbrough, I.S., Anderson, J.L.R., Carbery, D.R., Pudney, C.R. (2023) 'Synthetic Cannabinoid Receptor Agonists are Monoamine Oxidase-A Selective Inhibitors.' The Federation of European Biochemical Societies (FEBS) Journal, 290(12) pp. 3243-3257.
Andrews, R.C., May, B., Hernández, F.J., Cozier, G.E., Townsend, P.A., Sutcliffe, O.B., Haines, T.S.F., Freeman, T.P., Scott, J., Husbands, S.M., Blagbrough, I.S., Bowman, R.W., Lewis, S.E., Grayson, M.N., Crespo-Otero, R., Carbery, D.R., Pudney, C.R. (2023) 'Photochemical fingerprinting Is a sensitive probe for the detection of synthetic cannabinoid receptor agonists; toward robust point-of-care detection.' Analytical Chemistry, 95(2) pp. 703-713.
Naredo-Gonzalez, G., Upreti, R., Jansen, M.A., Semple, S., Sutcliffe, O.B., Marshall, I., Walker, B.R., Andrew, R. (2022) 'Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy.' Scientific Reports, 12(1) pp. 16268-16268.
Sutcliffe, O.B., Mewis, R.E., Kemsley, E.K., Williamson, D.C. (2022) '3,4-Methylenedioxymethamphetamine quantification via benchtop 1H qNMR spectroscopy: method validation and its application to ecstasy tablets collected at music festivals.' Journal of Pharmaceutical and Biomedical Analysis, 221pp. 115042-115042.
Dixon, D.I., Antonides, L.H., Costello, A., Crane, B., Embleton, A., Fletcher, M.L., Gilbert, N., Hulme, M.C., James, M.J., Lever, M.A., Maccallum, C.J., Millea, M.F., Pimlott, J.L., Robertson, T.B.R., Rudge, N.E., Schofield, C.J., Zukowicz, F., Kemsley, E.K., Sutcliffe, O., Mewis, R.E. (2022) 'Comparative study of the analysis of seized samples by GC-MS, 1H NMR and FT-IR spectroscopy within a Night-Time Economy (NTE) setting.' Journal of Phamaceutical and Biomedical Analysis, 219pp. 114950-114950.
Field, J.K., Hinz, C., Titman, C.M., Hulme, M.C., Cowan, R.M., Ainsworth-McMillan, J.B., Gilbert, N., Lee, R.J., Marron, J., Costello, A., Mewis, R.E., Euerby, M.R., Sutcliffe, O.B. (2022) 'Guilty by Dissociation: Part A: Development of a rapid Ultra-High Performance Liquid Chromatography (UHPLC)-MS/MS methodology for the analysis of regioisomeric diphenidine-derived Novel Psychoactive Substances (NPS).' Journal of Pharmaceutical and Biomedical Analysis, 216pp. 114798-114798.
Cochrane, G., Field, J.K., Hulme, M.C., Gilbert, N., Mewis, R.E., Euerby, M.R., Sutcliffe, O.B. (2022) 'Guilty by Dissociation: Part B: Evaluation of Supercritical Fluid Chromatography (SFC-UV) for the analysis of regioisomeric diphenidine-derived Novel Psychoactive Substances (NPS).' Journal of Pharmaceutical and Biomedical Analysis, 216pp. 114797-114797.
Kronstrand, R., Norman, C., Vikingsson, S., Biemans, A., Crespo, B.V., Edwards, D., Fletcher, D., Gilbert, N., Persson, M., Reid, R., Semenova, O., Alteneiji, F., Wu, X., Dahlen, J., NicDaeid, N., Tarbah, F., Sutcliffe, O.B., McKenzie, C., Green, H. (2021) 'The metabolism of the synthetic cannabinoids ADB‐BUTINACA and ADB‐4en‐PINACA and their detection in forensic toxicology casework and infused papers seized in prisons.' Drug Testing and Analysis, 14(4) pp. 634-652.
McNeill, L., Megson, D., Linton, P.E., Norrey, J., Bradley, L., Sutcliffe, O.B., Shaw, K.J. (2021) 'Lab-on-a-Chip approaches for the detection of controlled drugs, including new psychoactive substances: A systematic review.' Forensic Chemistry, 26pp. 100370-100370.
Gilbert, N., Costello, A., Ellison, J.R., Khan, U., Knight, M., Linnell, M.J., Ralphs, R., Mewis, R.E., Sutcliffe, O.B. (2021) 'Synthesis, characterisation, detection and quantification of a novel hexyl-substituted synthetic cannabinoid receptor agonist: (S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-hexyl-1H-indazole-3-carboxamide (ADB-HINACA).' Forensic Chemistry, 26pp. 100354-100354.
Ralphs, R., Gray, P., Sutcliffe, O.B. (2021) 'The impact of the 2016 Psychoactive Substances Act on synthetic cannabinoid use within the homeless population: markets, content and user harms.' International Journal of Drug Policy, 97pp. 103305-103305.
Robertson, T.B.R., Gilbert, N., Sutcliffe, O.B., Mewis, R.E. (2021) 'Hyperpolarisation of Mirfentanil by SABRE in the Presence of Heroin.' ChemPhysChem, 22(11) pp. 1059-1064.
Hulme, M.C., Hayatbakhsh, A., Brignall, R.M., Gilbert, N., Costello, A., Schofield, C.J., Williamson, D.C., Kemsley, E.K., Sutcliffe, O.B., Mewis, R.E. (2021) 'Detection, discrimination and quantification of amphetamine, cathinone and nor-ephedrine regioisomers using benchtop 1H and 19F NMR spectroscopy.' Magnetic Resonance in Chemistry (MRC), 61(2) pp. 73-82.
Gilbert, N., Mewis, R.E., Sutcliffe, O.B. (2021) 'Fast & Fluorinated – Development and validation of a rapid benchtop NMR approach and other routine screening methods for the detection and quantification of synthesised fluorofentanyl derivatives.' Forensic Chemistry, 23pp. 100321-100321.
McNeill, L., Pearson, C., Megson, D., Norrey, J., Watson, D., Ashworth, D., Linton, P.E., Sutcliffe, O.B., Shaw, K.J. (2020) 'Origami Chips: development and validation of a paper-based Lab-on-a-Chip device for the rapid and cost-effective detection of 4-methylmethcathinone (mephedrone) and its metabolite, 4-methylephedrine in urine.' Forensic Chemistry, 22pp. 100293-100293.
Antonides, L.H., Cannaert, A., Norman, C., Nic Daeid, N., Sutcliffe, O.B., Stove, C.P., McKenzie, C. (2020) 'Shape Matters: The Application of Activity‐Based In Vitro Bioassays and Chiral Profiling to the Pharmacological Evaluation of Synthetic Cannabinoid Receptor Agonists in Drug‐Infused Papers Seized in Prisons.' Drug Testing and Analysis, 13(3) pp. 628-643.
Gilbert, N., Mewis, R.E., Sutcliffe, O.B. (2020) 'Classification of fentanyl analogues through principal component analysis (PCA) and hierarchical clustering of GC–MS data.' Forensic Chemistry, 21
Hussain, J.H., Gilbert, N., Costello, A., Schofield, C.J., Kemsley, E.K., Sutcliffe, O.B., Mewis, R.E. (2020) 'Quantification of MDMA in seized tablets using benchtop 1H NMR spectroscopy in the absence of internal standards.' Forensic Chemistry, 20pp. 100263-100263.
Gilbert, N., Antonides, L.H., Schofield, C.J., Costello, A., Kilkelly, B., Cain, A.R., Dalziel, P.R.V., Horner, K., Mewis, R.E., Sutcliffe, O.B. (2020) 'Hitting the Jackpot – development of gas chromatography–mass spectrometry (GC–MS) and other rapid screening methods for the analysis of 18 fentanyl-derived synthetic opioids.' Drug Testing and Analysis, 12(6) pp. 798-811.
Tennant, T., Hulme, M.C., Robertson, T.B.R., Sutcliffe, O.B., Mewis, R.E. (2020) 'Benchtop NMR analysis of piperazine-based drugs hyperpolarised by SABRE.' Magnetic resonance in chemistry : MRC, 58(12) pp. 1151-1159.
Norman, C., Walker, G., McKirdy, B., McDonald, C., Fletcher, D., Antonides, L.H., Sutcliffe, O.B., Nic Daéid, N., McKenzie, C. (2020) 'Detection and quantitation of synthetic cannabinoid receptor agonists in infused papers from prisons in a constantly evolving illicit market.' Drug Testing and Analysis, 12(4) pp. 538-554.
Robertson, T.B.R., Antonides, L.H., Gilbert, N., Benjamin, S.L., Langley, S.K., Munro, L.J., Sutcliffe, O.B., Mewis, R.E. (2019) 'Hyperpolarization of Pyridyl Fentalogues by Signal Amplification By Reversible Exchange (SABRE).' ChemistryOpen, 8pp. 1-9.
Elbardisy, H.M., Foster, C.W., Marron, J., Mewis, R.E., Sutcliffe, O.B., Belal, T.S., Talaat, W., Daabees, H.G., Banks, C.E. (2019) 'Quick Test for Determination of N-Bombs (Phenethylamine Derivatives, NBOMe) Using High-Performance Liquid Chromatography: A Comparison between Photodiode Array and Amperometric Detection.' ACS Omega, 4(11) pp. 14439-14450.
Muhamadali, H., Watt, A., Xu, Y., Chisanga, M., Subaihi, A., Jones, C., Ellis, D.I., Sutcliffe, O.B., Goodacre, R. (2019) 'Rapid Detection and Quantification of Novel Psychoactive Substances (NPS) Using Raman Spectroscopy and Surface-Enhanced Raman Scattering.' Frontiers in Chemistry, 7
Antonides, L.H., Brignall, R.M., Costello, A., Ellison, J., Firth, S.E., Gilbert, N., Groom, B.J., Hudson, S.J., Hulme, M.C., Marron, J., Pullen, Z.A., Robertson, T.B.R., Schofield, C.J., Williamson, D.C., Kemsley, E.K., Sutcliffe, O.B., Mewis, R.E. (2019) 'Rapid Identification of Novel Psychoactive and Other Controlled Substances Using Low-Field 1H NMR Spectroscopy.' ACS Omega, 4(4) pp. 7103-7112.
Elbardisy, H.M., Foster, C.W., Cumba, L., Antonides, L.H., Gilbert, N., Schofield, C.J., Belal, T.S., Talaat, W., Sutcliffe, O.B., Daabees, H.G., Banks, C.E. (2019) 'Analytical determination of heroin, fentanyl and fentalogues using high-performance liquid chromatography with diode array and amperometric detection.' Analytical Methods, 11(8) pp. 1053-1063.
Elbardisy, H.M., Garcia-Miranda Ferrari, A., Foster, C.W., Sutcliffe, O.B., Brownson, D.A.C., Belal, T.S., Talaat, W., Daabees, H.G., Banks, C.E. (2019) 'Forensic Electrochemistry: The Electroanalytical Sensing of Mephedrone Metabolites.' ACS Omega, 4(1) pp. 1947-1954.
Antonides, L.H., Cannaert, A., Norman, C., Vives, L., Harrison, A., Costello, A., Nic Daeid, N., Stove, C.P., Sutcliffe, O.B., McKenzie, C. (2019) 'Enantiospecific Synthesis, Chiral Separation, and Biological Activity of Four Indazole-3-Carboxamide-Type Synthetic Cannabinoid Receptor Agonists and Their Detection in Seized Drug Samples..' Frontiers in Chemistry, 7pp. 321-321.
Caprio, V., McLachlan, A.S., Sutcliffe, O.B., Williamson, D.C., Mewis, R.E. (2018) 'Structural elucidation of unknowns: a spectroscopic investigation with an emphasis on 1D and 2D nuclear magnetic resonance spectroscopy.' Chemistry: Bulgarian Journal of Science Education, 27(2) pp. 223-234.
Lowdon, J.W., Alkirkit, S.M.O., Mewis, R.E., Fulton, D., Banks, C.E., Sutcliffe, O.B., Peeters, M. (2018) 'Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers..' Analyst, 143pp. 2002-2007.
McKenzie, C., Sutcliffe, O.B., Read, K.D., Scullion, P., Epemolu, O., Fletcher, D., Helander, A., Beck, O., Rylski, A., Antonides, L.H., Riley, J., Smith, S.A., Nic Daeid, N. (2018) 'Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users.' Forensic Toxicology, 36(2) pp. 359-374.
Boateng, B.O., Fever, M., Edwards, D., Petersson, P., Euerby, M.R., Sutcliffe, O.B. (2018) 'Chromatographic retention behaviour, modelling and optimization of a UHPLC-UV separation of the regioisomers of the Novel Psychoactive Substance (NPS) methoxphenidine (MXP).' Journal of Pharmaceutical and Biomedical Analysis, 153pp. 238-247.
Anthony, N.G., Baiget, J., Berretta, G., Boyd, M., Breen, D., Edwards, J., Gamble, C., Gray, A.I., Harvey, A.L., Hatziieremia, S., Ho, K.H., Huggan, J.K., Lang, S., Llona-Minguez, S., Luo, J.L., McIntosh, K., Paul, A., Plevin, R.J., Robertson, M.N., Scott, R., Suckling, C.J., Sutcliffe, O.B., Young, L.C., Mackay, S.P. (2017) 'Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers.' Journal of Medicinal Chemistry, 60(16) pp. 7043-7066.
Solà, R., Sutcliffe, O.B., Banks, C.E., Maciá, B. (2017) 'Ball mill and microwave assisted synthetic routes to Fluoxetine.' Sustainable Chemistry and Pharmacy, 5pp. 14-21.
Casadio, S., Lowdon, J.W., Betlem, K., Ueta, J.T., Foster, C.W., Cleij, T.J., van Grinsven, B., Sutcliffe, O.B., Banks, C.E., Peeters, M. (2017) 'Development of a novel flexible polymer-based biosensor platform for the thermal detection of noradrenaline in aqueous solutions.' Chemical Engineering Journal, 315pp. 459-468.
Khreit, O.I.G., Grant, H.M., Henderson, C., Watson, D.G., Sutcliffe, O.B. (2016) 'Identification of Novel Metabolic Pathways of Sitagliptin (STG) by LC/MS and LC/MS2 after Incubations with Rat Hepatocytes.' Journal of Drug Metabolism & Toxicology, 7(4)
Geyer, P.M., Hulme, M.C., Irving, J.P.B., Thompson, P.D., Ashton, R.N., Lee, R.J., Johnson, L., Marron, J., Banks, C.E., Sutcliffe, O.B. (2016) 'Guilty by dissociation—development of gas chromatography–mass spectrometry (GC-MS) and other rapid screening methods for the analysis of 13 diphenidine-derived new psychoactive substances (NPSs).' Analytical and Bioanalytical Chemistry, 408(29) pp. 8467-8481.
Cumba, L.R., Smith, J.P., Zuway, K.Y., Sutcliffe, O.B., do Carmoa, D.R., Banks, C.E. (2015) 'Forensic electrochemistry: simultaneous voltammetric detection of MDMA and its fatal counterpart "Dr Death" (PMA).' Analytical Methods, 8
Zuway, K.Y., Smith, J.P., Foster, C.W., Kapur, N., Banks, C.E., Sutcliffe, O.B. (2015) 'Detection and quantification of new psychoactive substances (NPSs) within the evolved "legal high" product, NRG-2, using high performance liquid chromatography-amperometric detection (HPLC-AD).' ANALYST, 140
Cumba, L.R., Kolliopoulos, A.V., Smith, J.P., Thompson, P.D., Evans, P.R., Sutcliffe, O.B., do Carmo, D.R., Banks, C.E. (2015) 'Forensic electrochemistry: indirect electrochemical sensing of the components of the new psychoactive substance "Synthacaine".' ANALYST, 140
Smith, J.P., Sutcliffe, O.B., Banks, C.E. (2015) 'An overview of recent developments in the analytical detection of new psychoactive substances (NPSs).' ANALYST, 140
Connor, L.E., Delori, A., Hutchison, I.B., Nic Daeid, N., Sutcliffe, O.B., Oswald, I.D.H. (2015) 'The ecstasy and the agony; Compression studies of 3,4-methylenedioxymethamphetamine (MDMA).' Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 71(1) pp. 3-9.
Igoli, J.O., Blackburn, G., Gray, A.I., Sutcliffe, O.B., Watson, D.G., Euerby, M.R., Skellern, G.G. (2015) 'Chromatographic and spectroscopic analysis of the components present in the phenanthridinium trypanocidal agent isometamidium.' Analytical and Bioanalytical Chemistry, 407(4) pp. 1171-1180.
Tan, F., Smith, J.P., Sutcliffe, O.B., Banks, C.E. (2015) 'Regal electrochemistry: Sensing of the synthetic cathinone class of new psychoactive substances (NPSs).' Analytical Methods, 7(16) pp. 6470-6474.
Sutcliffe, O.B., Skellern, G.G., Araya, F., Cannavan, A., Sasanya, J.J., Dungu, B., Van Gool, F., Münstermann, S., Mattioli, R.C. (2014) 'Animal trypanosomosis: Making quality control of trypanocidal drugs possible.' OIE Revue Scientifique et Technique, 33(3) pp. 813-820.
Smith, J.P., Foster, C.W., Metters, J.P., Sutcliffe, O.B., Banks, C.E. (2014) 'Metallic Impurities in Graphene Screen-Printed Electrodes Can Influence Their Electrochemical Properties.' Electroanalysis, 26(11) pp. 2429-2433.
Smith, J.P., Metters, J.P., Khreit, O.I.G., Sutcliffe, O.B., Banks, C.E. (2014) 'Forensic electrochemistry applied to the sensing of new psychoactive substances: Electroanalytical sensing of synthetic cathinones and analytical validation in the quantification of seized street samples.' Analytical Chemistry, 86(19) pp. 9985-9992.
Delori, A., Maclure, P., Bhardwaj, R.M., Johnston, A., Florence, A.J., Sutcliffe, O.B., Oswald, I.D.H. (2014) 'Drug solid solutions-a method for tuning phase transformations.' CrystEngComm, 16(26) pp. 5827-5831.
Apps, M.G., Johnson, B.W., Sutcliffe, O.B., Brown, S.D., Wheate, N.J. (2014) 'Amide coupling reaction for the synthesis of bispyridine-based ligands and their complexation to platinum as dinuclear anticancer agents.' Journal of Visualized Experiments, (87)
Nic Daeid, N., Savage, K.A., Ramsay, D., Holland, C., Sutcliffe, O.B. (2014) 'Development of gas chromatography-mass spectrometry (GC-MS) and other rapid screening methods for the analysis of 16 'legal high' cathinone derivatives.' Science and Justice, 54(1) pp. 22-31.
Santali, E.Y., Edwards, D., Sutcliffe, O.B., Bailes, S., Euerby, M.R., Watson, D.G. (2014) 'A comparison of silica C and silica gel in HILIC mode: The effect of stationary phase surface area.' Chromatographia, 77(13-14) pp. 873-881.
Satthaphut, N., Sutcliffe, O.B., Oswald, I.D.H. (2014) 'Putting the squeeze on mephedrone hydrogen sulfate.' Zeitschrift fur Kristallographie, 229(2) pp. 101-111.
Nic Daeid, N., Savage, K.A., Ramsay, D., Holland, C., Sutcliffe, O.B. (2014) 'Development of gas chromatography-mass spectrometry (GC-MS) and other rapid screening methods for the analysis of 16 'legal high' cathinone derivatives.' Science and Justice,
Smith, J.P., Metters, J.P., Irving, C., Sutcliffe, O.B., Banks, C.E. (2013) 'Forensic electrochemistry: the electroanalytical sensing of synthetic cathinone-derivatives and their accompanying adulterants in "legal high" products..' Analyst, 139(2) pp. 389-400.
Smith, J.P., Metters, J.P., Kampouris, D.K., Lledo-Fernandez, C., Sutcliffe, O.B., Banks, C.E. (2013) 'Forensic electrochemistry: the electroanalytical sensing of Rohypnol® (flunitrazepam) using screen-printed graphite electrodes without recourse for electrode or sample pre-treatment..' Analyst, 138(20) pp. 6185-6191.
Naredo-Gonzalez, G., Jansen, M., Upreti, R., Semple, S., Merrifield, G., Sutcliffe, O., Hansen, M., Marshall, I., Andrew, R., Walker, B. (2013) '19F-magnetic resonance spectroscopy as a tool to quantify 11[beta]-hydroxysteroid dehydrogenase activity in vivo.' Endocrine Abstracts, pp. 1-1.
Khreit, O.I.G., Grant, M.H., Zhang, T., Henderson, C., Watson, D.G., Sutcliffe, O.B. (2013) 'Elucidation of the Phase I and Phase II metabolic pathways of (±)-4'-methylmethcathinone (4-MMC) and (±)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS²..' J Pharm Biomed Anal, 72pp. 177-185.
Abualhasan, M.N., Batrawi, N., Sutcliffe, O.B., Zaid, A.N. (2012) 'A validated stability-indicating HPLC method for routine analysis of an injectable lincomycin and spectinomycin formulation.' Scientia Pharmaceutica, 80(4) pp. 977-986.
Brown, S.D., Trotter, K.D., Sutcliffe, O.B., Plumb, J.A., Waddell, B., Briggs, N.E.B., Wheate, N.J. (2012) 'Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity..' Dalton Trans, 41(37) pp. 11330-11339.
Bawazeer, S., Sutcliffe, O.B., Euerby, M.R., Bawazeer, S., Watson, D.G. (2012) 'A comparison of the chromatographic properties of silica gel and silicon hydride modified silica gels..' J Chromatogr A, 1263pp. 61-67.
NicDaéid, N., Meier-Augenstein, W., Kemp, H.F., Sutcliffe, O.B. (2012) 'Using isotopic fractionation to link precursor to product in the synthesis of (±)-mephedrone: a new tool for combating "legal high" drugs..' Anal Chem, 84(20) pp. 8691-8696.
Abualhasan, M.N., Good, J.A.D., Wittayanarakul, K., Anthony, N.G., Berretta, G., Rath, O., Kozielski, F., Sutcliffe, O.B., MacKay, S.P. (2012) 'Doing the methylene shuffle - Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl l-cysteine.' European Journal of Medicinal Chemistry, 54pp. 483-498.
Khreit, O.I.G., Irving, C., Schmidt, E., Parkinson, J.A., Nic Daeid, N., Sutcliffe, O.B. (2012) 'Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2.' Journal of Pharmaceutical and Biomedical Analysis, 61pp. 122-135.
Wang, F., Good, J.A.D., Rath, O., Kaan, H.Y.K., Sutcliffe, O.B., Mackay, S.P., Kozielski, F. (2012) 'Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity..' J Med Chem, 55(4) pp. 1511-1525.
Woo, L.W.L., Ganeshapillai, D., Thomas, M.P., Sutcliffe, O.B., Malini, B., Mahon, M.F., Purohit, A., Potter, B.V.L. (2011) 'Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495)..' ChemMedChem, 6(11) pp. 2019-2034.
Baiget, J., Llona-Minguez, S., Lang, S., MacKay, S.P., Suckling, C.J., Sutcliffe, O.B. (2011) 'Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b] indole-1-carboxylate: Concise synthesis of alangiobussinine.' Beilstein Journal of Organic Chemistry, 7pp. 1407-1411.
Santali, E.Y., Cadogan, A.K., Daeid, N.N., Savage, K.A., Sutcliffe, O.B. (2011) 'Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone): A new "legal high".' Journal of Pharmaceutical and Biomedical Analysis, 56(2) pp. 246-255.
Kirkpatrick, G.J., Plumb, J.A., Sutcliffe, O.B., Flint, D.J., Wheate, N.J. (2011) 'Evaluation of anionic half generation 3.5-6.5 poly(amidoamine) dendrimers as delivery vehicles for the active component of the anticancer drug cisplatin.' Journal of Inorganic Biochemistry, 105(9) pp. 1115-1122.
Clark, R.L., Johnston, B.F., Mackay, S.P., Breslin, C.J., Robertson, M.N., Sutcliffe, O.B., Dufton, M.J., Harvey, A.L. (2010) 'The drug discovery portal: A computational platform for identifying drug leads from academia.' Current Pharmaceutical Design, 16(15) pp. 1697-1702.
Wheate, N.J., Patel, N., Sutcliffe, O.B. (2010) 'Microwave synthesis of cucurbit[n]urils.' Future Medicinal Chemistry, 2(2) pp. 231-236.
Bubert, C., Woo, L.W.L., Sutcliffe, O.B., Mahon, M.F., Chander, S.K., Purohit, A., Reed, M.J., Potter, B.V.L. (2008) 'Synthesis of aromatase inhibitors and dual aromatase steroid sulfatase inhibitors by linking an arylsulfamate motif to 4-(4H-1,2,4-triazol-4-ylamino) benzonitrile: SAR, crystal structures, in vitro and in vivo activities.' ChemMedChem, 3(11) pp. 1708-1730.
Foster, P.A., Chander, S.K., Newman, S.P., Woo, L.W.L., Sutcliffe, O.B., Bubert, C., Zhou, D., Chen, S., Potter, B.V.L., Reed, M.J., Purohit, A. (2008) 'A new therapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitor..' Clin Cancer Res, 14(20) pp. 6469-6477.
Woo, L.W.L., Bubert, C., Sutcliffe, O.B., Smith, A., Chander, S.K., Mahon, M.F., Purohit, A., Reed, M.J., Potter, B.V.L. (2007) 'Dual aromatase-steroid sulfatase inhibitors.' Journal of Medicinal Chemistry, 50(15) pp. 3540-3560.
Lloyd, M.D., Thiyagarajan, N., Ho, Y.T., Woo, L.W.L., Sutcliffe, O.B., Purohit, A., Reed, M.J., Acharya, K.R., Potter, B.V.L. (2005) 'First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors.' Biochemistry, 44(18) pp. 6858-6866.
Sutcliffe, O.B., Bryce, M.R. (2003) 'Planar chiral 2-ferrocenyloxazolines and 1,1′-bis(oxazolinyl)ferrocenes - Syntheses and applications in asymmetric catalysis.' Tetrahedron Asymmetry, 14(16) pp. 2297-2325.
Woo, L.W.L., Sutcliffe, O.B., Bubert, C., Grasso, A., Chander, S.K., Purohit, A., Reed, M.J., Potter, B.V.L. (2003) 'First dual aromatase-steroid sulfatase inhibitors.' Journal of Medicinal Chemistry, 46(15) pp. 3193-3196.
Sutcliffe, O.B., Bryce, M.R., Batsanov, A.S. (2002) 'Synthesis of novel chiral bis(ferrocenyl) ligands and their use as voltammetric metal cation sensors.' Journal of Organometallic Chemistry, 656(1-2) pp. 211-216.
Sutcliffe, O.B., Chesney, A., Bryce, M.R. (2001) 'Voltammetric metal cation sensors based on ferrocene derivatives with oxazoline and imine substituents.' Journal of Organometallic Chemistry, 637-639pp. 134-138.
Sutcliffe, O.B., Storr, R.C., Gilchrist, T.L., Rafferty, P. (2001) 'Azafulvenium methides: New extended dipolar systems.' Journal of the Chemical Society. Perkin Transactions 1, 15pp. 1795-1806.
Sutcliffe, O.B., Storr, R.C., Gilchrist, T.L., Rafferty, P. (2000) 'Cycloadditions to pyrrolo[1,2-c]thiazoles and pyrazolo[1,5-c]thiazoles.' Tetrahedron, 56(51) pp. 10011-10021.
Sutcliffe, O.B., Storr, R.C., Gilchrist, T.L., Rafferty, P., Crew, A.P.A. (2000) 'Azafulvenium methides: New extended dipolar systems.' Chemical Communications, (8) pp. 675-676.
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Conference papers
Brandon, A., Harries, R., Sutcliffe, O.B., Nisbet, L. (2023) 'Lipophilicity, plasma protein binding and intrinsic clearance of fentanyl analogues.' In Annual Society of Forensic Toxicologists Meeting. Denver, CO, 29/10/2023 - 2/11/2023.
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Presentations
Sutcliffe, O.B. (2022) MANDRAKE, Manchester and Drug Awareness. [Presentation] Virtual,15/11/2022.
Sutcliffe, O.B. (2022) MANDRAKE – Testing & Harm Reduction in the UK Prison System. [Presentation] Warrington, UK,25/7/2022.
Sutcliffe, O.B. (2022) Manchester - a journey through time and Spice. [Presentation] SciX2022, Liverpool UK,11/4/2022.
Sutcliffe, O.B. (2022) MANDRAKE – Testing & Harm Reduction in the Community. [Presentation] Virtual,18/1/2022.
Sutcliffe, O.B., Costello, A. (2021) Manchester – a journey through time and Spice. [Presentation] Online,23/6/2021.
Sutcliffe, O.B., Costello, A. (2021) Spice and Other Street Drugs – A Manchester-led Solution to a UK problem. [Presentation] 16/6/2021.
Sutcliffe, O.B., Costello, A. (2021) Spice and Other Street Drugs – A Manchester-led Solution to a UK problem. [Presentation] Online,18/5/2021.
Sutcliffe, O.B., Costello, A. (2020) Spice and Other Street Drugs – A Manchester-led Solution to a UK problem. [Presentation] Public Lecture, Manchester Metropolitan University,25/11/2020.
McNeill, L.F., Savvos, M., Sutcliffe, O.B., Megson, D.P., Linton, P.E., Shaw, K.J. (2019) Rapid and portable presumptive testing of new psychoactive substances. [Presentation] 1/1/2019.
Sutcliffe, O.B. (2018) Addressing the challenges of New Psychoactive Substance detection within frontline environments. [Presentation] Crowne Plaza, Hawthorn Square, Forth Street, Newcastle upon Tyne NE1 3SA,8/11/2018.
Sutcliffe, O., Costello, A. (2018) In-situ Detection of Psychoactive Substances in a Custodial Setting. [Presentation] 23/10/2018.
Sutcliffe, O., Costello, A. (2018) Spice and other Street Drugs - A Manchester-led Solution for a UK Problem. [Presentation] Roscoe Building, University of Manchester, Manchester, UK.,10/10/2018.
Sutcliffe, O.B. (2018) Racked by Spice: Tackling NPS in Greater Manchester. [Presentation] Manchester Metropolitan University,19/3/2018.
Wang, Q., Recio-Toro, D., Lee-Jones, L., Sutcliffe, O., Linton, P., Ferris, G. (2017) Investigation of the effects of new potential drugs on leukaemia cells in vitro. [Presentation] Liverpool, UK,5/11/2017.
Sutcliffe, O.B. (2017) Polarizing Poison – Novel Spectroscopic Methods for Detecting New Psychoactive Substances. [Presentation] 5th International Conference on Novel Psychoactive Substances, Vienna, Austria,24/10/2017.
Sutcliffe, O.B. (2017) Racked by Spice – Tackling NPS in Greater Manchester. [Presentation] London Toxicology Group Meeting, London, UK,29/9/2017.
Sutcliffe, O.B. (2017) Greater Manchester Police – A Year On. [Presentation] UK New Psychoactive Substances Conference, Kettering, UK,24/5/2017.
Sutcliffe, O.B. (2017) Polarizing Poison – Novel Spectroscopic Methods for Detecting New Psychoactive Substances. [Presentation] Exploring the challenges with Novel Psychoactive Substances Conference, York, UK,3/3/2017.
Wang, Q., Recio-Toro, D., Lee-Jones, L., Sutcliffe, O., Linton, P., Ferris, G. (2017) Investigation of the effects of new potential drugs on leukaemia cells in vitro.. [Presentation] 2017.
Sutcliffe, O.B. (2016) Testing Times – Pros & Cons of Analytical Testing Techniques. [Presentation] Testing Times Conference, Manchester,UK,6/6/2016.
Pearson, C., Sutcliffe, O.B., Shaw, K.J. (2016) The M-CAT's out of the bag: A paper-based microfluidic immunoassay for the rapid detection of mephedrone. [Presentation] 2016.
Holmes, P., McNeill, L., Sutcliffe, O.B., Shaw, K.J. (2016) Guilty by dissociation: Paper-fluidic presumptive testing of the new psychoactive substance, diphenidine. [Presentation] 2016.
Sutcliffe, O.B. (2015) New Psychoactive Substances – New Forensic Challenges. [Presentation] Drugs & Alcohol Today Conference, Manchester, UK,11/2/2015.
Owen, F.H. (2015) Using isotopic fractionation to link precursor to product in the synthesis of diphenidine hydrochloride: a tool for combating new psychoactive substances (NPSs). [Presentation]
Sutcliffe, O.B., Nic Daeid, N., Kemp, H., Meier-Augenstein, W. (2012) The efficacy of isotope ratio mass spectrometry to link precursor to final product in cathinone-derived “legal high” drugs. [Presentation] European Geosciences Union (EGU), Vienna, Austria,22/4/2012.
Good, J.A.D., Wang, F., Rath, O., Kaan, H.Y.K., Podgorski, D., Sutcliffe, O.B., Mackay, S.P., Kozielski, F. (2012) Development of S-trityl L-cysteine based inhibitors of the mitotic kinesin Eg5 with in vivo antitumor activity. [Presentation] San Diego, CA,25/3/2012.
Sutcliffe, O.B. (2011) Characterization of Novel Drugs of Abuse: Mephedrone and Analogues. [Presentation] 38th FACSS International Meeting, Reno USA,2/10/2011.
Sutcliffe, O.B. (2011) New tests for dangerous 'legal marijuana,' 'bath salts' and other emerging designer drugs. [Presentation] 30/8/2011.
Sutcliffe, O.B., Daeid, N.N., Khreit, O.I.G. (2011) Tackling the forensic analytical challenges associated with the global increase in seizures of cathinone-derived \"legal highs\". [Presentation] Denver, CO,28/8/2011.
Sutcliffe, O.B., Santali, E.Y., Cadogan, A.K., Nic Daeid, N., Savage, K.A. (2011) Demystifying mephedrone. [Presentation] 5th Saudi International Postgraduate Conference (SIC05), Coventry, UK,23/6/2011.
Sutcliffe, O.B., Cadogan, A.K., Nic Daeid, N., Savage, K.A. (2011) Chemical characterization of mephedrone. [Presentation] Conference on Analytical Sciences Ireland 2011, Dublin, Ireland,21/2/2011.
Abualhasan, M., Sutcliffe, O.B., Kozielski, F., Mackay, S.P. (2010) Design and Synthesis of Novel EG5 Inhibitors. [Presentation] 1/10/2010.
Sutcliffe, O.B., Santali, E.Y., Cadogan, A.K., Nic Daeid, N., Savage, K.A. (2010) Demystifying mephedrone. [Presentation] UK & Ireland Forensic Toxicology Network, Glasgow, UK,6/9/2010.
Sutcliffe, O.B., Cadogan, A.K., Santali, E.Y., Nic Daeid, N., Savage, K.A. (2010) Rapid analysis of mephedrone. [Presentation] UK & Ireland Forensic Toxicology Network, Glasgow, UK,6/9/2010.
Naredo-Gonzalez, G., Jansen, M.A., Merrifield, G.D., Sutcliffe, O.B., Hansen, M.K., Andrew, R., Walker, B.R. (2010) Non-Invasive In-Vivo Monitoring of 11 beta-HSD1 Activity Using F-19-Magnetic Resonance Spectroscopy.. [Presentation] San Diego, CA,1/6/2010.
Sutcliffe, O.B., Reed, M.J., Purohit, A., Woo, L.W.L., Chander, S.K., Bubert, C., Potter, B.V.L. (2003) The development of potent dual aromatase-sulfatase inhibitors (DASI) for breast cancer therapy. [Presentation] Endocrine Society (85th Annual Meeting, ENDO 2003), Philadelphia, USA,19/6/2003.
Sutcliffe, O.B., Woo, L.W.L., Bubert, C., Robinson, J.J., Grasso, A., Chander, S.K., Purohit, A., Reed, M.J., Potter, B.V.L. (2003) First dual aromatase-steroid sulfatase inhibitors. [Presentation] IVth International Workshop on Steroidogenesis, Bath, UK,24/4/2003.
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Patents
Sutcliffe, O.B., Mewis, R., Williamson, D. (2018) A method for screening psychoactive substances.
Sutcliffe, O.B., Ferro, V.A., Mullen, A.B., Bennett, E., Gebril, A.M. (2017) Preparation of Non-Ionic Surfactant Vesicles and Variants.
Sutcliffe, O.B., Potter, B.V.L., Reed, M.J., Purohit, A., Woo, L.W.L., Bubert, C. (2014) 1,2,4-Triazole derivative containing sulphamate group as aromatase inhibitor.
Sutcliffe, O.B., Potter, B.V.L., Reed, M.J., Woo, L.W.L., Purohit, A., Bubert, C. (2013) Compound Patent.
Sutcliffe, O.B., Potter, B.V.L., Woo, L.W.L., Purohit, A., Reed, M.J., Bubert, C. (2013) 1,2,4-Triazole derivatives containing a sulphamate group as aromatase inhibitors.
Sutcliffe, O.B., Potter, B.V.L., Reed, M.J., Woo, L.W.L., Purohit, A., Bubert, C., Wood, M.P. (2012) Sulfamic acid ester compounds useful in the inhibition of steroid sulphates activity and aromatase activity.
Sutcliffe, O.B., Potter, B.V.L., Woo, L.W.L., Purohit, A., Reed, M.J., Bubert, C., Wood, M.P. (2012) Sulfamic acid ester compounds useful in the inhibition of steroid sulphates activity and aromatase activity.
Sutcliffe, O.B., Potter, B.V.L., Reed, M.J., Woo, L.W.L., Purohit, A., Wood, M.P., Bubert, C. (2012) Sulfamic acid ester compounds useful in the inhibition of steroid sulphatase activity and aromatase activity.
Sutcliffe, O.B., Potter, B.V.L., Woo, L.W.L., Reed, M.J., Purohit, A., Bubert, C. (2009) Compound Patent.
Sutcliffe, O.B., Potter, B.V.L., Woo, L.W.L., Purohit, A., Reed, M.J., Bubert, C. (2008) Polycyclic sulphamate compounds suitable for use as inhibitors of aromatase and/or sulphatase.
Sutcliffe, O.B., Potter, B.V.L., Woo, L.W.L., Reed, M.J., Purohit, A., Bubert, C., Wood, M.P. (2007) Sulfamic acid ester compounds useful in the inhibition of steroid sulphatase activity and aromatase activity.
Sutcliffe, O.B., Potter, B.V.L., Woo, L.W.L., Reed, M.J., Purohit, A., Bubert, C. (2006) Compound Patent.
Sutcliffe, O.B., Potter, B.V.L., Reed, M.J., Woo, L.W.L., Bubert, C., Wood, M.P. (2006) Sulfamic acid ester compounds useful in the inhibition of steroid sulphatase activity and aromatase activity.
Sutcliffe, O.B., Potter, B.V.L., Woo, L.W.L., Reed, M.J., Purohit, A., Wood, M.P., Bubert, C. (2005) Sulfamic acid ester compounds useful in the inhibition of steroid sulphatase activity and aromatase activity.
Sutcliffe, O.B., Potter, B.V.L.P., Woo, L.W.L., Purohit, A., Reed, M.J., Bubert, C. (2004) Compound Patent.
Sutcliffe, O.B., Potter, B.V.L., Woo, L.W.L., Reed, M.J., Purohit, A., Bubert, C. (2003) 1,2,4-Triazole derivatives containing a sulphamate group as aromatase inhibitors.
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Posters
Barrett, B., Euerby, M., Field, J., Gilbert, N., Moreau, S., Sutcliffe, O.B. (2024) 'Separation and quantification of novel synthetic regioisomeric fentanyls in clinical extracts by high pH reverse-phase LC-MS/MS.' [Poster] In International Symposium of Chromatography (ISC 2024), Liverpool, UK. Date viewed 7/10/2024.
Barnes, A., Schein, P., Dixon, D.I., Millea, M.F., Armitage, E.G., Barrett, B., Mewis, R.E., Sutcliffe, O.B., Loftus, N.J. (2024) 'Characterization of new psychoactive substances using high resolution mass spectrometry structural assignment software.' [Poster] Date viewed 6/6/2024.
Press and media
Dr Sutcliffe’s expert opinion on illicit drugs/new psychoactive substances is sought for media appearances and he leads a programme of public engagement via social media (Twitter: @MANDRAKE_LAB and Instagram: mandrake_lab) to disseminate drug alerts/harm reduction messaging to warn about new and/or novel drugs.
Data from the RKE/REF Impact & Engagement Team shows his total media reach (>180 media appearances) is approximately 342 million people across 10 countries including Germany and the United States.
Dr Sutcliffe’s media engagement profile has resulted in a substantial amount of advertising revenue (AVE) for Manchester Metropolitan totalling at least £3.1M.
Dr Sutcliffe’s research has resulted in a Spice “primer” article published in the Conversation (>800k reads) and appeared in the feature-length UNILAD original documentary “The Dark Side of Britain: Spice” (Age Verification Required) [Backup Link]. This film has had over 2.6 million views on YouTube, with 16,000 likes. It is UNILAD’s fifth most watched YouTube documentary video of all time (out of 200), with over 5,000 viewer comments (ranked second highest for comments). Public reaction has been sustained over two years, with thoughtful and emotional viewer comments posted every week since release.