Dr Mun-Kit Choy
Dr Mun-Kit Choy PhD (Cantab), FHEA
Senior Lecturer in Cardiovascular Science
My profile
Biography
I have an interest in using stem cell/differentiation models to understand the cardiovascular system through chromosomal interactomics and other genomic approaches. I have an extensive track record of investigating the interactomic, epigenomic or transcriptomic regulation in the development and pathogenesis of the heart.
Honorary positions: Honorary Senior Research Fellow (The University of Manchester), Life Member (Clare Hall, University of Cambridge), International Collaborative Partner (University of Tunku Abdul Rahman, Malaysia)
Professional membership: The British Society For Cardiovascular Research
Research outputs
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Journal articles
Liu, Y., Choy, M.K., Abraham, S., Tenin, G., Black, G.C., Keavney, B.D. (2023) 'Atrial Septal Defect (ASD) associated long non-coding RNA STX18-AS1 maintains time-course of in vitro cardiomyocyte differentiation.' Genes & Diseases, 10(4) pp. 1150-1153.
Liu, Y., Choy, M.K., Abraham, S., Tenin, G., Black, G.C., Keavney, B.D. (2022) 'Data on cardiac lncRNA STX18-AS1 expression in developing human hearts and function during in vitro hESC-cardiomyocyte differentiation.' Data in Brief, 45pp. 108770-108770.
Liu, Y., Williams, S.G., Jones, H.R., Keavney, B.D., Choy, M.K. (2021) 'A novel RNA-mediated mechanism causing down-regulation of insulating promoter interactions in human embryonic stem cells.' Scientific Reports, 11(1) pp. 23233-23233.
Liu, Y., Chen, S., Zühlke, L., Babu-Narayan, S.V., Black, G.C., Choy, M.K., Li, N., Keavney, B.D. (2020) 'Global prevalence of congenital heart disease in school-age children: a meta-analysis and systematic review.' BMC Cardiovascular Disorders, 20(1)
Liu, Y., Chen, S., Zühlke, L., Black, G.C., Choy, M.K., Li, N., Keavney, B.D. (2019) 'Global birth prevalence of congenital heart defects 1970–2017: updated systematic review and meta-analysis of 260 studies.' International Journal of Epidemiology, 48(2) pp. 455-463.
Choy, M.K., Javierre, B.M., Williams, S.G., Baross, S.L., Liu, Y., Wingett, S.W., Akbarov, A., Wallace, C., Freire-Pritchett, P., Rugg-Gunn, P.J., Spivakov, M., Fraser, P., Keavney, B.D. (2018) 'Author Correction: Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks (Nature Communications, (2018), 9, 1, (2526), 10.1038/s41467-018-04931-0).' Nature Communications, 9(1)
Choy, M.K., Javierre, B.M., Williams, S.G., Baross, S.L., Liu, Y., Wingett, S.W., Akbarov, A., Wallace, C., Freire-Pritchett, P., Rugg-Gunn, P.J., Spivakov, M., Fraser, P., Keavney, B.D. (2018) 'Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.' Nature Communications, 9(1) pp. 2526-2526.
Martin, R.I.R., Babaei, M.S., Choy, M.K., Owens, W.A., Chico, T.J.A., Keenan, D., Yonan, N., Koref, M.S., Keavney, B.D. (2015) 'Genetic variants associated with risk of atrial fibrillation regulate expression of PITX2, CAV1, MYOZ1, C9orf3 and FANCC.' Journal of Molecular and Cellular Cardiology, 85pp. 207-214.
Haider, S., Cordeddu, L., Robinson, E., Movassagh, M., Siggens, L., Vujic, A., Choy, M.K., Goddard, M., Lio, P., Foo, R. (2012) 'The landscape of DNA repeat elements in human heart failure.' Genome Biology, 13(10) pp. R90-R90.
Movassagh, M., Choy, M.K., Knowles, D.A., Cordeddu, L., Haider, S., Down, T., Siggens, L., Vujic, A., Simeoni, I., Penkett, C., Goddard, M., Lio, P., Bennett, M.R., Foo, R.S.Y. (2011) 'Distinct Epigenomic Features in End-Stage Failing Human Hearts.' Circulation, 124(22) pp. 2411-2422.
Choy, M., Movassagh, M., Foo, R. (2011) 'The human variome: genomic and epigenomic diversity.' EMBO Molecular Medicine, 3(10) pp. 573-574.
Choy, M.K., Movassagh, M., Goh, H.G., Bennett, M.R., Down, T.A., Foo, R.S.Y. (2010) 'Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated.' BMC Genomics, 11(1)
Choy, M.K., Movassagh, M., Siggens, L., Vujic, A., Goddard, M., Sanchez, A., Perkins, N., Figg, N., Bennett, M., Carroll, J., Foo, R. (2010) 'High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53 - NF-kappaB - complex-dependent gene expression in human heart failure.' Genome Medicine, 2(6) pp. 37-37.
Choy, M.K., Phipps, M.E. (2010) 'MICA polymorphism: biology and importance in immunity and disease.' Trends in Molecular Medicine, 16(3) pp. 97-106.
Choy, M., Movassagh, M., Bennett, M.R., Foo, R.S. (2010) 'PKB/Akt activation inhibits p53‐mediated HIF1A degradation that is independent of MDM2.' Journal of Cellular Physiology, 222(3) pp. 635-639.
Movassagh, M., Choy, M.K., Goddard, M., Bennett, M.R., Down, T.A., Foo, R.S.Y. (2010) 'Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure..' PloS one, 5(1)
Choy, M.K., Sullivan, J.A., Theobald, J.C., Davies, W.J., Gray, J.C. (2008) 'An Arabidopsis mutant able to green after extended dark periods shows decreased transcripts of seed protein genes and altered sensitivity to abscisic acid.' Journal of Experimental Botany, 59(14) pp. 3869-3884.
Dunn, D.S., Choy, M.K., Phipps, M.E., Kulski, J.K. (2007) 'The distribution of major histocompatibility complex class I polymorphic Alu insertions and their associations with HLA alleles in a Chinese population from Malaysia.' Tissue Antigens, 70(2) pp. 136-143.
Choy, M.K., Phipps, M.E. (2003) 'Possible Polyphyletic Origin of Major Histocompatibility Complex Class I Chain-Related Gene A (MICA) Alleles.' Journal of Molecular Evolution, 57(1) pp. 38-43.
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Conference papers
Choy, M.K., Liu, Y., Williams, S., Eales, J., Keavney, B. (2022) 'BS13 Genome-wide association study coupled with promoter interactomic data identifies neuroplastin (NPTN) as a potential novel gene regulating heart rate.' In British Cardiovascular Society Annual Conference: 100 years of Cardiology. 108. Manchester, UK, 6/6/2022 - 8/6/2022. London: BMJ Publishing Group, pp. A151-A152.
Career history
2013-2023
Research Fellow in Cardiovascular Genomics (The University of Manchester)
2013-2010
BHF Post-Doctoral Research Fellow (University of Cambridge)