Dr Can Zhao

Dr Can Zhao

Dr Can Zhao

Lecturer in Microbiology

My profile

Get in touch

John Dalton Building

Research outputs

PATENTS

  1. Zhao C, Bromley M J, Read N D, Vendrell M E (2022) Antifungal therapeutic and fungal diagnostic compounds in relation to fungal keratitis. UK priority filling number: 2109478.4.

PEER REVIEWED PUBLICATIONS (Orcid ID: https://orcid.org/ 0000-0002-0508-0236)

  1. Mendive-Tapia L, Mendive-Tapia D, Zhao C, Gordon D, Bromley M, Wang W, Wu J, Kopp A, Ackermann L & Vendrel M. Rational Design of Phe-BODIPYs as Fluorogenic Building Blocks for Peptide based Detection of Urinary Tract Candida Infections. Angewandte Chemie (2022)
  2. Niu M, Steffan BN, Fischer GJ, Venkatesh N, Raffa NL, Wettstein MA, Bok JW, Greco C, Zhao C, Berthier E, Oliw E, Beebe D, Bromley M, Keller NP. Fungal oxylipins direct programmed developmental switches in filamentous fungi. Nat Comm. (2020)
  3. Furukawa T, Scheven MT, Misslinger M, Zhao C, Hoefgen S, Gsaller F, Lau J, Jöchl C, Donaldson I, Valiante V, Brakhage AA, Bromley MJ, Haas H, Hortschansky P. The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition. Nucleic Acids Res (2020).
  4. Van Rhijn N, Furukawa T, Zhao C, McCann BL, Bignell E, Bromley M. Development of a marker-free mutagenesis system using CRISPR-Cas9 in the pathogenic mould Aspergillus fumigatus. Fungal Genet Biol (2020)
  5. Zhao C, Fraczek M, Dineen L, Lebedinec R, Macheleidt J, Heinekamp T, Delneri D, Bowyer P, Brakhage AA, & Bromley M. High throughput gene replacement in Aspergillus fumigatus, Current Protocols in Microbiology(2019).
  6. Zhao C†, Mendive L & Vendrell M†. Fluorescent peptides for imaging of fungal cells. Arch Biochem Biophys(2019).
  7. Fraczek M, Zhao C., Dineen L, Lebedinec R, Bowyer P, Bromley M & Delneri D. Fast and reliable PCR amplification from Aspergillus fumigatus spore suspension without traditional DNAextraction, Current Protocols in Microbiology (2019).
  8. Scott J, Sueiro Olivares M, Ahmed W, Heddergott C, Zhao C, Thomas R, Bromley M, Latgé JP, Krappmann S, Fowler S, Bignell E & Amich Elias J. Pseudomonas aeruginosa-derived volatile sulphur compounds promote distal Aspergillus fumigatus growth and a synergistic pathogenpathogen interaction that increases pathogenicity in co-infection, Frontiers in Microbiology (2019).
  9. Mendive L†, Subiros-Funosas R†, Zhao C†, Albericio F, Read N, Lavilla R and Vendrell M. Preparation and use of a BODIPY fluorogenic amino acid for minimally invasive labeling of peptides and enhanced live cell fluorescence imaging. Nature Protoc. 12, 1588–1619 (2017). 
  10. Zhao C, Fernandez A, Avlonitis N, Velde G, Bradley M, Read N and Vendrell M. Searching for the optimal fluorophore in antimicrobial peptide sequences. ACS Comb Sci. 18, 11 (2017).
  11. Mendive L, Zhao C, Akram A, Preciado S, Albericio F, Lee M, Serrels A, Kielland N, Read N, Lavilla R and Vendrell M. Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue. Nature Comm. 7:10940 (2016).

  • Journal articles

    van Rhijn, N., Zhao, C., Al-Furaji, N., Storer, I.S.R., Valero, C., Gago, S., Chown, H., Baldin, C., Grant, R.F., Bin Shuraym, H., Ivanova, L., Kniemeyer, O., Krüger, T., Bignell, E., Goldman, G.H., Amich, J., Delneri, D., Bowyer, P., Brakhage, A.A., Haas, H., Bromley, M.J. (2024) 'Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging.' Nature Communications, 15(1)

    Mendive-Tapia, L., Mendive-Tapia, D., Zhao, C., Gordon, D., Benson, S., Bromley, M.J., Wang, W., Wu, J., Kopp, A., Ackermann, L., Vendrell, M. (2022) 'Rational Design of Phe-BODIPY Amino Acids as Fluorogenic Building Blocks for Peptide-Based Detection of Urinary Tract Candida Infections.' Angewandte Chemie International Edition, 61(17)

    van Rhijn, N., Furukawa, T., Zhao, C., McCann, B.L., Bignell, E., Bromley, M.J. (2020) 'Development of a marker-free mutagenesis system using CRISPR-Cas9 in the pathogenic mould Aspergillus fumigatus.' Fungal Genetics and Biology, 145

    Niu, M., Steffan, B.N., Fischer, G.J., Venkatesh, N., Raffa, N.L., Wettstein, M.A., Bok, J.W., Greco, C., Zhao, C., Berthier, E., Oliw, E., Beebe, D., Bromley, M., Keller, N.P. (2020) 'Fungal oxylipins direct programmed developmental switches in filamentous fungi.' Nature Communications, 11(1)

    Furukawa, T., Scheven, M.T., Misslinger, M., Zhao, C., Hoefgen, S., Gsaller, F., Lau, J., Jöchl, C., Donaldson, I., Valiante, V., Brakhage, A.A., Bromley, M.J., Haas, H., Hortschansky, P. (2020) 'The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition.' Nucleic Acids Research, 48(7) pp. 3567-3590.

    Scott, J., Sueiro-Olivares, M., Ahmed, W., Heddergott, C., Zhao, C., Thomas, R., Bromley, M., Latgé, J.P., Krappmann, S., Fowler, S., Bignell, E., Amich, J. (2019) 'Pseudomonas aeruginosa-Derived Volatile Sulfur Compounds Promote Distal Aspergillus fumigatus Growth and a Synergistic Pathogen-Pathogen Interaction That Increases Pathogenicity in Co-infection.' Frontiers in Microbiology, 10

    Fraczek, M.G., Zhao, C., Dineen, L., Lebedinec, R., Bowyer, P., Bromley, M., Delneri, D. (2019) 'Fast and Reliable PCR Amplification from Aspergillus fumigatus Spore Suspension Without Traditional DNA Extraction.' Current Protocols in Microbiology, 54(1)

    Zhao, C., Fraczek, M.G., Dineen, L., Lebedinec, R., Macheleidt, J., Heinekamp, T., Delneri, D., Bowyer, P., Brakhage, A.A., Bromley, M. (2019) 'High-Throughput Gene Replacement in Aspergillus fumigatus.' Current Protocols in Microbiology, 54(1)

    Zhao, C., Mendive-Tapia, L., Vendrell, M. (2019) 'Fluorescent peptides for imaging of fungal cells.' Archives of Biochemistry and Biophysics, 661pp. 187-195.

    Mendive-Tapia, L., Subiros-Funosas, R., Zhao, C., Albericio, F., Read, N.D., Lavilla, R., Vendrell, M. (2017) 'Preparation of a Trp-BODIPY fluorogenic amino acid to label peptides for enhanced live-cell fluorescence imaging.' Nature Protocols, 12(8) pp. 1588-1619.

    Zhao, C., Fernandez, A., Avlonitis, N., Vande Velde, G., Bradley, M., Read, N.D., Vendrell, M. (2016) 'Searching for the Optimal Fluorophore to Label Antimicrobial Peptides.' ACS Combinatorial Science, 18(11) pp. 689-696.

    Mendive-Tapia, L., Zhao, C., Akram, A.R., Preciado, S., Albericio, F., Lee, M., Serrels, A., Kielland, N., Read, N.D., Lavilla, R., Vendrell, M. (2016) 'Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue.' Nature Communications, 7

  • Patents

    Zhao, C., Bromley, M.J., Read, N.D., Vendrell, M.E. (2022) Antifungal therapeutic and fungal diagnostic compounds in relation to fungal keratitis.

Career history