Christopher Broughton
Christopher Broughton
Tutor
Tutor in the Department of Life Sciences, teaching across Undergraduate and Masters courses in Biomedical Science and Human Physiology
My profile
Biography
I am a molecular biology researcher with an interest in haemato-oncology, specifically B cell malignancies. I have a background in NHS clinical research and extensive teaching experience in a broad range of topics across Biomedical Science and Physiology.
Interests and expertise
Interests
- B cell malignancies
- B cell receptor signalling
- Drug repurposing
- Cell cycle checkpoint control
- Tubulin dynamics
Expertise
- Cell culture
- Microscopy (brightfield/confocal)
- Flow cytometry (apoptosis/cell cycle)
- RT-qPCR
- Multiplex western blotting
Projects
My PhD project (DoS: Dr Nina Dempsey) investigated the use of novel thienopyridine compounds as potential anti-cancer agents in B cell maligancies.
Research outputs
British Society for Haematology (BSH) Virtual ASM, Online 2020, Poster Presentation
- Broughton, C., Edwards, K., Whitehead, K., Van Rensburg M., Pilkington L., Reynisson J., Barker D., Dempsey-Hibbert, N. (2020) ‘BSH2020-EP-085 Novel synthetic thienopyridine derivatives induce tubulin disruption and cell cycle arrest in malignant B cells with level of activity related to their chemical structure’, British Journal of Haematology, 189(Suppl. 1), pp. 227-228
European Hematology Association (BSH) Virtual Congress, Online 2020, Poster Presentation
- Broughton, C., Edwards, K., Whitehead, K., Van Rensburg M., Pilkington L., Reynisson J., Barker D., Dempsey-Hibbert, N. (2020) ‘PB1899 Novel Thienopyridine Derivatives Induce Tubulin Disruption, Cause Cell Cycle Arrest And Inhibit Activation Of PLCG2 In Malignant B-Cells’, HemaSphere, 4(S1), pp. 865
European Hematology Association (EHA) Congress, Amsterdam 2019, Poster Presentation
- Broughton, C., Edwards, K., Whitehead, K., Van Rensburg M., Pilkington L., Reynisson J., Barker D., Dempsey-Hibbert, N. (2019) ‘PF523 Novel Thienopyridine Derivatives Induce Tubulin Disruption And Cause Cell Cycle Arrest In Malignant B-Cells’, HemaSphere, 3(S1), pp. 214
MMU Science & Engineering Research Symposium, Manchester 2017, Poster Presentation
- Broughton, C., Graham, C., Whitehead, K., Dempsey-Hibbert, N. (2017) ‘In-vitro effects of novel thienopyridine and thiazinoquinone derivatives on immortalised cancer cell lines’.
European Group for Blood and Marrow Transplantation (EBMT) Conference, Paris 2011, Poster Presentation
- Yin, J.A., Tholouli, E., Lucas, G., Goldstone, J., Narayan, S., Kok-Shun, J., Natarajan, S., Choudhuri, S., Broughton, C., Waller, M., Hurlin, J., Smith, E., Deakin, D., Lenehan, H., and Adams, J. (2011) ‘Outcome Of HSC Transplantation For Leukaemia After Myeloablative Conditioning Using TBI (1,000 CGY) Delivered In 2 Fractions, The Manchester Royal Infirmary, UK, Experience’, Bone Marrow Transplantation, 46, pp. S272-S272.